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Combination List

Combination drug:

Losartan is used alone or in combination with hydrochlorothiazide (Hyzaar®) in the treatment of high blood pressure. It is a type of drug called an angiotensin II receptor antagonist.


Summary of Interactions for Losartan

Depletion or interference None known
Adverse interaction None known
Side effect reduction/prevention None known
Supportive interaction None known
Reduced drug absorption/bioavailability None known
Other (see text) Potassium

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Interactions with Supplements


Losartan has caused significant increases in blood potassium levels.1 Potassium supplements, potassium-containing salt substitutes (No Salt, Morton Salt Substitute, and others), and even high-potassium foods (primarily fruit) should be avoided by those taking losartan, unless directed otherwise by their doctor.

Other Interactions


The intestinal absorption of losartan may be reduced up to 10% if taken with food.2 Although this is a minor reduction, losartan should be taken an hour before or two hours after food for maximum effectiveness.


  1. Perazella MA. Drug-induced hyperkalemia: Old culprits and new offenders. Am J Med 2000;109:307-14 [review].
  2. Sifton DW, ed. Physicians Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 1769-72.

Last Review: 01-21-2009


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Topic Contents
 Combination List
 Interactions with Supplements
 Other Interactions