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Losartan is used alone or in combination with hydrochlorothiazide (Hyzaar®) in the treatment of high blood pressure. It is a type of drug called an angiotensin II receptor antagonist.
Summary of Interactions for Losartan
|Depletion or interference ||None known|
|Adverse interaction ||None known|
|Side effect reduction/prevention ||None known|
|Supportive interaction ||None known|
|Reduced drug absorption/bioavailability ||None known|
|Other (see text) ||Potassium|
An asterisk (*) next to an item in the summary
indicates that the interaction is supported only by weak, fragmentary,
and/or contradictory scientific evidence.
Interactions with Supplements
Losartan has caused significant increases in blood potassium levels.1 Potassium supplements, potassium-containing salt substitutes (No Salt, Morton Salt Substitute, and others), and even high-potassium foods (primarily fruit) should be avoided by those taking losartan, unless directed otherwise by their doctor.
The intestinal absorption of losartan may be reduced up to 10% if taken with food.2 Although this is a minor reduction, losartan should be taken an hour before or two hours after food for maximum effectiveness.
- Perazella MA. Drug-induced hyperkalemia: Old culprits and new offenders. Am J Med 2000;109:307-14 [review].
- Sifton DW, ed. Physicians Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 1769-72.
Last Review: 01-21-2009
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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires August 2010.