Calcium-Channel Blockers

Alternative Medicine
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Also indexed as:

Bepadin, Bepridil, Cardene, DynaCirc, Isradipine, Lacidipine, Lercanidipine, Nicardipine, Nimodipine, Nimotop, Nisoldipine, Sular, Vascor

Calcium-channel blockers are a family of drugs used to treat angina, high blood pressure, heart arrhythmia, heart failure, and Raynaud's disease, as well as to prevent migraine headaches.

For interactions involving specific calcium-channel blocking drugs, refer to the highlighted medications listed below.


  • Amlodipine (Norvasc®)
  • Bepridil (Bepadin®, Vascor®)
  • Diltiazem (Cardizem®, Dilacor XR®, Tiazac®)
  • Felodipine (Plendil®)
  • Isradipine (DynaCirc®)
  • Nicardipine (Cardene®)
  • Nifedipine (Adalat®, Procardia®)
  • Nimodipine (Nimotop®)
  • Nisoldipine (Sular®)
  • Verapamil (Calan®, Covera H-S®, Isoptin®, Verelan®)


Summary of Interactions for Calcium Channel Blockers

Depletion or interference None known
Adverse interaction Pleurisy root
Side effect reduction/prevention None known
Supportive interaction None known
Reduced drug absorption/bioavailability None known
Interactions common to many, if not all, Calcium Channel Blockers are described in this article. Interactions reported for only one or several drugs in this class may not be listed in this article. Some drugs listed in this article are linked to articles specific to that respective drug; please refer to those individual drug articles. The information in this article may not necessarily apply to drugs in this class for which no separate article exists. If you are taking a Calcium Channel Blocker for which no separate article exists, talk with your doctor or pharmacist.

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Interactions with Herbs

Pleurisy root

As pleurisy root and other plants in the Aesclepius genus contain cardiac glycosides, it is best to avoid use of pleurisy root with heart medications such as calcium channel blockers.1


  1. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: Pharmaceutical Press, 1996, 213-4.

Last Review: 01-21-2009


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